By incorporating four functional motifs that include D-peptidomimetic inhibitor of PD-L1, matrix metalloproteinase-2 (MMP-2) cleavable spacer, and MP9 with 4-arm PEG, a novel peptide-polymer conjugate (PEG-MP9-aPDL1) was obtained and identified as the most promising systemic delivery vehicle with PD-L1 targeting specificity and favorable pharmacokinetic properties. Methods: Based on wasp venom peptide, an optimized stapled oncolytic peptide MP9 was developed with rigid α-helix, protease-resistance, and CRC cell cytotoxicity. However, the clinical application of oncolytic peptides has been hindered because of structural instability, proteolytic degradation, and undesired toxicity when administered systemically.
Oncolytic peptides rise as a promising therapeutic approach that boosts tumor-specific immune responses by inducing antigenic substances. Rationale: Scarce tumor mutation burden and neoantigens create tremendous obstacles for an effective immunotherapy of colorectal cancer (CRC). Select the file that you have just downloaded and select import option Reference Manager (RIS).
#Stapled peptide download
Available fromĬlick on Go to download the file. Polymer chimera of stapled oncolytic peptide coupled with anti-PD-L1 peptide boosts immunotherapy of colorectal cancer. Lu L, Zhang H, Zhou Y, Lin J, Gao W, Yang T, Jin J, Zhang L, Nagle DG, Zhang W, Wu Y, Chen H, Luan X.
✉ Corresponding authors: Ye Wu, wuyeedu.cn Hongzhuan Chen, hongzhuan_chencom Xin Luan, luanxinedu.cn. *These authors contributed equally to this work. Department of BioMolecular Sciences and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA Department of Chemistry and Biochemistry, College of Liberal Arts, University of Mississippi, University, MS, 38677-1848, USAĤ. School of Pharmacy, Fudan University, Shanghai, 201203, China.ģ. Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, ChinaĢ. Nagle 1,4, Weidong Zhang 1, Ye Wu 1, Hongzhuan Chen 1, Xin Luan 1ġ. Lu Lu 1*, He Zhang 1,2*, Yudong Zhou 1,3*, Jiayi Lin 1, Weidong Gao 1, Ting Yang 1, Jinmei Jin 1, Lijun Zhang 1, Dale G. Research Paper Polymer chimera of stapled oncolytic peptide coupled with anti-PD-L1 peptide boosts immunotherapy of colorectal cancer
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